Synchrotron Radiation Clinical Trial for Dogs with Soft Tissue Sarcoma

This clinical trial is exploring a potential limb-sparing treatment option for selected dogs with distal limb soft tissue sarcoma (tumours located below the elbow or below the stifle), where amputation would otherwise be recommended to achieve tumour control.

The study uses Synchrotron radiation therapy to deliver a highly targeted radiation dose in carefully selected cases.

Current Study Status

One place remains in the current phase of this study.

Veterinarians or owners with a potentially suitable patient are encouraged to contact Arthur to discuss eligibility.

Background

Dr Arthur House and Dr Eleanor Woolley have collaborated with nuclear physicists and medical radiation therapists from the Australian Nuclear Science and Technology Organisation (ANSTO) at the Australian Synchrotron to develop this pilot study.

Soft tissue sarcomas affecting the lower limbs can be challenging to treat surgically, particularly when tumour location limits the ability to achieve adequate margins. This study aims to evaluate whether Synchrotron radiation may provide an alternative pathway for selected patients.

What Participation Involves

Dogs enrolled in the study typically undergo:

• Clinical assessment and tumour staging

• Treatment planning prior to radiation therapy

• A single Synchrotron radiation treatment session under general anaesthesia

• Structured follow-up monitoring

• Surgical tumour resection where indicated, usually several weeks following treatment

Eligibility

Dogs may be considered for the study if they:

• Have a confirmed distal limb soft tissue sarcoma (below the elbow or below the stifle)

• Are suitable candidates for general anaesthesia

• Have no evidence of known metastatic or systemic disease on staging

• Are assessed as appropriate for the study pathway prior to surgery

Final eligibility is determined following clinical review.

Referrals and Enquiries

Veterinarians with potential candidates, or owners seeking further information, are welcome to contact:

Dr Arthur House
arthur@drarthurhouse.com.au